1、用法不同：be similar to后边既可以加物主代词又可以加人，即：be similar to sth/sb be similar with后边只可以加人 ，即be similar with sb.

例句：

（1）Drop in the earth, down to the river, went straight to the natural away, andChiang Kai-shek peaceful purpose 。

滴在土里，下到河里，直奔了自然而去的，中正平和，应与琴旨相近吧。

（2）I know, I suppose it must be similar to the River-Boca rivalry.

我知道。我想这和河床与博卡之间的竞争差不多。

2、是否可以加从句：be similar to后边可以跟从句，而be similar with不可以。

例句：

（1）To legalize it will be similar to that of horse-racing if this proposal is passed.

合法化会相似，赛马如果这项建议获得通过。

（2）The core technology of tissue engineering is utilize the suitable seed-cells compound with organic materials to build a cartilage-like tissue in vitro or in vivo, 

软骨组织工程的核心技术就是利用合适的种子细胞复合生物材料，在体内或体外构建与人关节透明软骨形态、结构。

3、释义不完全相同：be similar with 是某人对什么很熟悉 ，是主动 ；be similar to 是某物为某人所熟知，与...相似 , 是被动。

例句：

（1）Be similar with economic spatial distribution，the characteristic of populationspatial distribution is spatial centrality.

经济的空间分布具有集中性特点，人口的空间分布及演化亦是如此。

（2）That would be similar to what apple did with music and the iPod.

这听起来与苹果处理音乐和iPod的做法如出一辙。